URINARY TRACT INFECTIONS IN MEN: LABORATORY TESTS AND TREATMENT
Posted: under Men's Health-Erectile Dysfunction.
Laboratory Tests
In men, urine cultures should always be performed. Midstream urine collection is unnecessary in men. Even in uncircumcised men, the likelihood of contamination is low. Culture is considered positive with a CFU exceeding 103/ml of one organism.
Based on history and physical examination findings, acute uncomplicated cystitis is difficult to differentiate from prostatitis. Three-glass or four-glass testing can help to localize the infection.21 First-void (urethral), midstream (bladder), and end-stream (bladder) urine samples are collected and cultured. A fourth sample is obtained by expressing secretions through prostatic massage. Infection is localized to the prostate if the prostatic samples (end-void or prostatic secretions) yield a 10-fold greater colony count than the first-void sample. Most clinicians do not routinely perform these tests because they are cumbersome, expensive, and not well standardized. Some clinicians opt to perform simple urinalysis on three- or four-glass specimens. In men whose culture findings are negative, testing for gonorrhea and chlamydia should be performed. Other possible pathogens include Ureaplasma, Trichomonas, and herpes simplex virus.
Treatment
Antibiotic choice in men is similar to that in women. However, beta-lactams and nitrofurantoin tend to be less effective, since they do not achieve high concentrations within the prostate gland. Fluoroquinolones are generally favored, and men are typically treated for 7 to 14 days. Recurrent infection likely represents residual prostatic infection, in which case retreatment for 4 to 6 weeks is prudent.
Follow-Up
About one third of young men with one UTI have demonstrable (on renal ultrasonogram, intravenous pyelogram, or voiding cystourethrogram) urinary tract defects. However, these numbers may not differ much from women’s and usually do not affect treatment. Isolated infections are treated with 7 to 10 days of antibiotics, and frequent infections (more than two per year) are treated with prophylaxis. Most experts do not recommend urologic evaluation for men with a single UTI.
*2/348/5*